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The TPM and nicotine deliveries in the 1960s are based on testing performed by Philip Morris while TPM and nicotine yields reported from 1970 to 1990 are based on FTC reports
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Oxidation of keto aldehyde results in keto acid formation which is detectable in urine and the principal urinary metabolite of NNK in rodents and primates [66]
In contrast, the two multi-country clusters further divide, each forming two sub-clusters labeled Sub-Cluster 3.1, Sub-Cluster 3.2, Sub-Cluster 4.1, and Sub-Cluster 4.2, respectively (see Figure 14)
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